Fever.

London : University of London Audio-Visual Centre, 1971.

1 encoded moving image (31.09 min.) : sound, black and white.

00:31:09

University of London

Unrestricted

CC-BY-NC

Creative Commons Attribution-Non-Commercial 2.0 UK: England & Wales

In English

With Professor WI Cranston, St Thomas's Hospital Medical School, University of London. Introduced by Dr Ian Gilliland. Produced by Peter Bowen. Made by University of London Audio-Visual Centre. Made for British Postgraduate Medical Federation.

This video is one of around 310 titles, originally broadcast on Channel 7 of the ILEA closed-circuit television network, given to Wellcome Trust from the University of London Audio-Visual Centre shortly after it closed in the late 1980s. Although some of these programmes might now seem rather out-dated, they probably represent the largest and most diversified body of medical video produced in any British university at this time, and give a comprehensive and fascinating view of the state of medical and surgical research and practice in the 1970s and 1980s, thus constituting a contemporary medical-historical archive of great interest.The lectures mostly take place in a small and intimate studio setting and are often face-to-face. The lecturers use a wide variety of resources to illustrate their points, including film clips, slides, graphs, animated diagrams, charts and tables as well as 3-dimensional models and display boards with movable pieces. Some of the lecturers are telegenic while some are clearly less comfortable about being recorded; all are experts in their field and show great enthusiasm to share both the latest research and the historical context of their specialist areas.

Segment 1 Gilliland introduces Cranston. Cranston briefly narrates the history of research into the understanding of fever.He shows how endotoxin was injected into patients with typhoid fever in an attempt to lower their fever. Time start: 00:00:00:00 Time end: 00:05:05:00 Length: 00:05:05:00

Segment 2 Cranston refers to a graph which compares the temperature readings of a volunteer following injection with a bacterial pyrogen, firstly in saline then after having been incubated in blood. Bacterial and leukocyte pyrogens are also compared. Time start: 00:05:05:00 Time end: 00:10:29:00 Length: 00:05:24:00

Segment 3 Cranston describes how leukocyte pyrogens are formed from white cells. Time start: 00:10:29:00 Time end: 00:15:06:00 Length: 00:04:37:00

Segment 4 A diagram is shown which reveals which areas of the brain react to infusions of leukocyte pyrogen then further diagrams explaining how leukocyte pyrogens lead to a rise in temperature. These levels are showin in a patient with malaria. Time start: 00:15:06:00 Time end: 00:21:05:10 Length: 00:05:59:10

Segment 5 Cranston describes an experiment in which temperature is measured in a healthy individual after leukocytes have been infused and after cancerous kidney cells have been injected. He concludes the lecture by admitting that the philosophical question about the general value of fever remains unanswered. Time start: 00:21:05:10 Time end: 00:25:49:17 Length: 00:04:44:07