The Lumleian lectures on some moot point in the pathology and clinical history of pneumonia : delivered before the Royal College of Physicians of London on May 30th and June 4th and 6th, 1912 / by Percy Kidd.
- Kidd, Percy
- Date:
- [1912]
Licence: In copyright
Credit: The Lumleian lectures on some moot point in the pathology and clinical history of pneumonia : delivered before the Royal College of Physicians of London on May 30th and June 4th and 6th, 1912 / by Percy Kidd. Source: Wellcome Collection.
Provider: This material has been provided by London School of Hygiene & Tropical Medicine Library & Archives Service. The original may be consulted at London School of Hygiene & Tropical Medicine Library & Archives Service.
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![iiammatory lesions are found at the seat of inoculation, but the animal succumbs to a septicaemia. When cultures of low virulence are inoculated into the pleura or peri- toneum, fibrinous exudations are produced, from which the animal dies in several days, or it may recover. In this case no septicaemic symptoms arise. In none of the above conditions are definite pulmonary changes produced. If, however, cultures be injected into the trachea, or be inhaled, the lungs show hyperaemia and partial consolidation, but not true fibrinous pneumonia. But in resistant animals like the rat, large doses of cul- tures injected subcutaneously are said to give rise to considerable areas of consolidation resembling croupous pneumonia [2]. Wadsworth [3] found that in rabbits partially immunized by injections of pneumococcal cultures subsequent intra- tracheal injections of virulent diplococci did not give rise to general infection ; but if the animal were not too highly immunized caused pulmonary lesions comparable to those of lobar pneumonia in man. Similar lesions have been produced in the sheep and dog, which are very resistant to the pneumococcus, by direct injection of pneumococcal culture into the lung. But the conditions here are so entirely different from those met with in pneumonia in the human subject that the experiments are of little value. Quite recently Lamar and Meltzer [4] have succeeded in producing fibrinous lobar pneumonia in dogs by intrabronchial injections of bouillon culture of pneumococci. The anatomical features varied accord- ing to the stage of the disease and corresponded to the stages found in man. Man is evidently endowed with great powers of resist- ance to the pneumococcus, as shown by the high per- centage of recovery in pneumonia. Further, in cases comparable to pneumococcal septicaemia of animals, recovery is not uncommon in the human subject. It appears, therefore, that in the more acute pneumococcal infections, in which the cultures are very virulent, and in](https://iiif.wellcomecollection.org/image/b21353487_0010.jp2/full/800%2C/0/default.jpg)
