Chemical examination of the bark of Euonymus atropurpureus / by Harold Rogerson.

  • Rogerson, Harold.
Date:
1912
Catalogue details

Licence: In copyright

Credit: Chemical examination of the bark of Euonymus atropurpureus / by Harold Rogerson. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    A silver salt of the acid, which was precipitated in three fractions gave Ag = 296, 29'8, and 30'2 respectively: C1(iH3202 requires C = 75 0; H = 12'5; Ag = 29 7 per cent. Neutralisation Value = 219. It would appear that this fraction consisted of palmitic acid with a small amount of a lower acid. Fractions 2, 3, and 4 solidified to crystalline masses, and they were separately hydrolysed. The regenerated acids when recrystai- lised from ethyl acetate separated in laminae melting at 61—63°, 61—63°, and 60—61° respectively. Each fraction was found by analysis to consist of palmitic acid. (Found, C = 75'0; H = 12-6. C = 74-7; H = 12’5. C = 750; H = 125 respectively. Calc., C = 750; H = 12‘5 per cent.) Fraction 5 did not solidify on long keeping, but deposited a few laminae on cooling. It was hydrolysed, when palmitic acid (m. p. 60—61°) was obtained, together with a small amount of unsaturated acid. Fraction 240—280°/15 mm.—This fraction, which amounted to 5 grams, was hydrolysed, and the regenerated acid recrystallised first from alcohol and then fractionally from ethyl acetate. Three fractions were thus obtained, which consisted of shining laminae melting at 75—76°, 74—76°, and 75—77° respectively. After drying at 110° they were analysed: 0-1486 gave0-4264 CO, and 0‘1756 H,0. C = 78'3; H = 131. 0-1002 „ 0-2856 CCt, „ 0T194 H20. C = 77’7; H = 13’2. 0-1041 „ 0-2970 C02 „ 0T212 H20. C = 77'8; H = 129. C26H5202 requires C = 788; H = 13’l per cent. It would thus appear that the product from the last-mentioned fraction of esters consisted of cerotic acid, together with some lower acid. Ether, Chloroform, Ethyl Acetate, and- Alcohol Extracts of the Resin. These extracts were dark crimson masses, amounting to 150, 39, 50, and 30 grams respectively. They possessed a. bitter taste, especi- ally the portion soluble only in alcohol. Nothing definite could be obtained from any of them, nor were they glucosidic. Summary. The results of the present investigation may briefly be summar- ised as follows: The material employed for this investigation consisted of the root-bark of Euonyrnus airopurpureus, Jacquiu. An alcoholic
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