Chemical structure and sympathomimetic action of amines / by G. Barger and H.H. Dale.

  • George Barger
Date:
1910
Catalogue details

Licence: Attribution 4.0 International (CC BY 4.0)

Credit: Chemical structure and sympathomimetic action of amines / by G. Barger and H.H. Dale. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    Most of the above substances were obtained from well-known commercial sources: where necessary they were purified by recrystal- lising their salts. No. (11) was prepared from n. octyliodide and ammonia; Nos. (12)—(14) by Jefferies’ method from the amide of the next higher acid; No. (15) by electrolytic reduction of cyclo-hexanone- oxime. All were tested in ^ solutions as hydrochlorides. The most active members of the group are found among the primary amines. In the doses which were used—1 to 2 c.c. of the ^ solution—the activity did not extend in any significant degree to members lower in the series than n. butylamine, which in activity comes immediately below iso. ainylamine, the type-member, for us, of the series. Iso. butylamine had practically no pressor effect in the dosage indicated, though doubtless, if injected in lai-ger volume or stronger solution, it, and even lower members of the series, could be shown to possess a perceptible pressor effect. Under such conditions mere volume-effects complicate the record, and we only mention the probability of such activity in order to avoid the suggestion that a new characteristic suddenly appears in the series. The relative weakness of the iso. as compared with the normal bases is shown by the amylamiues as well as the butylamines. Iso. ainylamine Fig. 1. [Figs. 1 to 4, 6, 8 to 10, 14 and 15 show carotid blood-pressure. Injections intravenous. Bases as hydrochlorides.] N At A, A, 1 c.c. — n. ainylamine. II, ,, ,, i*o. ainylamine.