Mandamine : for urinary antisepsis / Menley & James, Ltd.

  • Menley & James.
Date:
1949
Catalogue details

Licence: Public Domain Mark

Credit: Mandamine : for urinary antisepsis / Menley & James, Ltd. Source: Wellcome Collection.

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    In a discussion of ‘Mandamine’ in their authoritative work, Clinical Urology, Lowsley and Kirwin? state that the urine will often be cleared of organisms in from 3 to 5 days, although in certain cases it has been necessary to persist with the treatment for a longer period. Dietary restriction and control of fluid intake are un- necessary with ‘Mandamine’,)»*>3 and this absence of restriction is generally found to be a significant contribution toward the convenience of the treatment. LACK OF TOXICITY The impressive lack of toxicity shown by ‘Mandamine’ facilitates treatment and simplifies the task of selecting patients. The evidences of intoxication so often seen when using other forms of mandelic acid—nausea, vomiting, and gastro-intestinal discomfort—have not been observed by investigators into ‘Mandamine’ treatment.2 Carroll and Allen! conclude that the drug is virtually non-toxic in therapeutic dosage. The absence of toxicity makes ‘Mandamine’ especially suitable for use during pregnancy, for children, and in stubborn or inoperable cases where treatment is necessarily prolonged. The only major contra-indication to ‘Mandamine’ is renal insufficiency. THERAPEUTIC ACTIVITY OF ‘*MANDAMINE’ Bacterial Resistance In the selection of a urinary antiseptic an important consideration must be the likelihood of bacterial resistance developing to the chosen medicament. Studies by Duca
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