Animal experimentation and tuberculosis / E. L. Trudeau.

  • Trudeau, Edward Livingston, 1848-1915.
Date:
1913
Catalogue details

Licence: Public Domain Mark

Credit: Animal experimentation and tuberculosis / E. L. Trudeau. Source: Wellcome Collection.

Provider: This material has been provided by the Harvey Cushing/John Hay Whitney Medical Library at Yale University, through the Medical Heritage Library. The original may be consulted at the Harvey Cushing/John Hay Whitney Medical Library at Yale University.

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    and cattle, the danger of tuberculous sputum and milk, and the identity of scrofulous disease and tuberculosis in man, as well as tuberculous disease in animals, by subcutaneous injection, by inhalation, and by ingestion experiments on animals, and established the value of animal inoculations in the diagnosis of suspected tuber- culous disease (a method which gives evidence from which there is no appeal) before the birth of bacteriol- ogy and before the tubercle bacillus was discovered by Koch. Koch's22 epoch-marking paper on the etiology of tu- berculosis, announcing his discovery of the tubercle bacillus as the direct cause of all tuberculous and scro- fulous diseases in man and animals, appeared in 1882. The unbroken chain of evidence forged by Koch in his logical demonstration of proof was obtained entirely by carefully controlled animal experiments, and gave the world a discovery of incalculable importance to the human race. Koch confirmed Cohnheim's views as to infectivencss being the best criterion of tuberculous dis- ease, and by animal experiments established the value of microscopic search for the bacillus in diagnosis, and the identity of many lesions hitherto looked on as due to different diseases on account of the marked differences they presented both clinically and in the pathologic find- ings, lie proved that all contained the same bacillus, which, when cultivated outside of the body, produced by inoculation in animals typical tuberculous lesions. Miliary tuberculosis, fibrous phthisis, caseous pneumo- nia, as well as scrofulous disease of glands, bones, and lupus of the skin, also Perlsucht in cattle, he showed to be due to the same cause—the tubercle bacillus. PROPHYLAXIS, DIAGNOSIS AND THERAPY In 1890 Koeh-':: demonstrated by careful animal ex- periments the diagnostic value of tuberculin, pointed out its specific action on the course of the disease and on tuberculous lesions, and proposed the tuberculin test as a practical and efficient method of eradicating tuberculosis from infected herds, and tuberculin injections as a therapeutic measure in the treatment of the disease in 22 Koch, K. l>le Aetiologie die Tuberkulose. Berl. klin. Wchnscbi. 1882, No. 15. 23. Koch, R. : Deutsili. mcd. Wchnschr.. Nov. 13. 1S90. No. -li'.a ; Oct 22, ls'.'i. No. •«;■..