Effects of hexamethonium on normal individuals in relation to its concentration in the plasma / by Brenda Morrison and W.D.M. Paton.

  • Morrison, Brenda
Date:
[1953?]
Catalogue details

Licence: In copyright

Credit: Effects of hexamethonium on normal individuals in relation to its concentration in the plasma / by Brenda Morrison and W.D.M. Paton. Source: Wellcome Collection.

    11/18 page 11
    Concentration of Hexainethoniiini in ttie Plasma Fig. 3 showed a typical graph of the rise and fall of concentration of hexamethonium in the plasma after a sub¬ cutaneous injection. To show the extent of variation in shape of such curves they have all been superimposed (Fig. 6). Correction for dose and body weight has not been made, since this would alter the height but not the form of the curves. Fig. 7 shows the standing blood-pressure changes and plasma-concentration curve for the subject who showed the most rapid absorption. The three phases of the curve—that is, the rise, the peak value, and the subsequent fall—considered pharmaco¬ logically, correspond to the three factors determining the plasma levels—that is, the rate of absorption, the volume of body fluid in which the hexamethonium is dissolved, and its rate of excretion by the kidney. These three aspects are considered in turn. Fig. 7.—Plasma concentration curve and standing blood pressures in the subject who showed the most rapid absorption of hexamethonium after subcutaneous injection.
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