The constituents of chaulmoogra seeds / by Frederick B. Power and Frank H. Gornall.
- Frederick Belding Power
- Date:
- [1904]
Licence: In copyright
Credit: The constituents of chaulmoogra seeds / by Frederick B. Power and Frank H. Gornall. Source: Wellcome Collection.
10/20 page 845
![wax in a vacuum desiccator in order to eliminate the last trace of ether. The solidified product then melted at 44—45°, had a specific rotatory power [a]D +52*6° in chloroform, the “acid value ” 215, and the “ iodine value ” 103 2. The absence of hydroxy-acids in this mixture was proved by the fact that, on treatment with acetic anhydride according to Lewko- witsch’s method (J'. Soc. Ghem. Incl., 1890, 9, 84G), no acetylation took place. Fractional Crystallisation of the Fatty Acids. For the examination of the fatty acids, which obviously represented a mixture of substances, 7250 grams were dissolved in 20 litres of hot 94 per cent, alcohol. When left overnight, the cold solution yielded 2300 grams of a distinctly crystalline acid. This was again crystal¬ lised, in the first instance from alcohol (90 per cent.), and finally from light petroleum, when 1100 grams of an acid were obtained which separated from the latter solvent in glistening leaflets melting at 68°, and this melting point remained unaltered by further crystallisations from a variety of solvents. By removing the solvent from the first of the last two mother liquors, 800 grams of residue remained. In order to eliminate a small amount of resinous matter, and thus obtain the substance in a form better adapted for analysis and the determination of constants, a portion was dissolved in an alcoholic solution of potassium hydroxide, the solution concentrated as far as possible, the potassium salt dis¬ solved in water, and the solution extracted several times with light petroleum. The aqueous solution was then acidified, the liberated acids taken up with ether, the ethereal solution washed, dried, and the solvent removed, in the first instance by distillation, and subse¬ quently by exposure of the warm, melted acid in a vacuum desiccator over paraffin wax. The white, solid acids thus obtained melted at 34—35°. The last-mentioned, petroleum mother liquor was also treated in a similar manner. The residue, after the removal of the solvent, weighed 400 grams, and, after purification from resinous matter, the melting point of the fraction was 59—61°. Having initially separated a large amount of an individual acid (m. p. 68°), which will subsequently be described, the first mother liquor was diluted with a small volume of water, which precipitated a quantity of substance, and this was again dissolved by raising the temperature a few degrees. On cooling, there separated from this solution a fraction of solid acids which weighed 2500 grams; a portion of this product, after the removal of some resinous matter, melted at 43-—44°. The mother liquor from this fraction was then diluted with](https://iiif.wellcomecollection.org/image/b30606627_0010.jp2/full/800%2C/0/default.jpg)
