The constituents of chaulmoogra seeds / by Frederick B. Power and Frank H. Gornall.

  • Frederick Belding Power
Date:
[1904]
Catalogue details

Licence: In copyright

Credit: The constituents of chaulmoogra seeds / by Frederick B. Power and Frank H. Gornall. Source: Wellcome Collection.

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    ether, and on removing the latter a small amount of a highly aromatic, yellow, oily liquid was obtained, which evidently consisted of a mixture of volatile acids and esters, but distilled over too wide a range of temperature to permit of their further investigation. The acid remaining in the distillate was converted into a barium salt, and from this a silver salt was prepared, the chief portion of which was soluble in hot water and crystallised on cooling. 0T008 gave 0*0652 Ag. Ag = 64*7. C2H300Ag requires Ag = 64*7 per cent. This volatile acid was therefore acetic acid. The extract was then repeatedly treated with hot water, the mixture allowed to cool, and placed on a strainer. A considerable amount of solid fatty matter was thus separated from a dark aqueous liquid, in which some viscid oil was suspended. The solid fat yielded on hydrolysis a quantity of fatty acids, which are probably identical with those contained in the oil expressed from the seeds, and contain a very small amount of formic acid. The aqueous liquid strained from the solid fat was extracted with chloroform, which removed a large amount of oily substance ; this was hydrolysed with alcoholic potassium hydroxide, the alcohol removed, the residual potassium salt taken up with water, and the strongly alkaline liquid extracted with ether. The combined ethereal liquids were washed with a little water, dried, and the ether removed. An oily liquid which was thus obtained was fractionally distilled under 18 mm. pressure, and thus resolved into (1) a very small fraction which passed over below 212°; (2) the principal fraction, which boiled between 212° and 220°; (3) a small fraction between 220° and 240°, but which passed over chiefly at 220—225° ; and (4) a small amount of dark residue containing a little phytosterol (compare p. 844). In order to ensure the complete freedom of this neutral liquid from any trace of fatty acids arising from the dissociation of their alkali salts in the process for its separation, the above-mentioned fraction, 212—220°/18 mm., was dissolved in ether and the solution shaken out many times with a concentrated solution of potassium hydroxide. The ethereal liquid was then washed, dried, the ether removed, and the residual, light yellow oil again distilled. It passed over almost entirely at 213—220°/18 mm., as a nearly colourless, odourless liquid, the greater portion distilling at 214—215°T8 mm. A portion boiling at the latter temperature was taken for analysis and the determination of its constants. 0*1403 gave 0*3967 C02 and 0*1455 H.,0. C = 77*l; H-11'5. 0*1053 „ 0*2989 C02 „ 0*1100 h“20. C-77‘4; H-11'6.
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