The influence of cocaine, atropine, and caffeine on the heart and bloodvessels / by H.G. Beyer.
- Beyer, Henry Gustav, 1850-1918.
- Date:
- 1885
Licence: Public Domain Mark
Credit: The influence of cocaine, atropine, and caffeine on the heart and bloodvessels / by H.G. Beyer. Source: Wellcome Collection.
Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.
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![Work Time. Rate in c.c. P.M. p. rain. p. niin. 38 38 44 48 38 45 50 38 47 65 40 47 2.03 40 47 07 40 47 12 40 48 14 40 .50 17 40 47 2] 40 47.5 30 40 49 35 40 47 87 41 51 41 41 46 45 42 49 50 41 46 55 41 48 57 4.3 49 3.02 43 49 10 43 48 15 45 45 20 44 45 25 42 46 30 42 46 32 40 49 34 42 A(i *u 36 42 46 41 43 .50 45 42 47 50 41 51 42 46 ' 55 42 46 4.00 42 46 06 40 42 08 41 42 13 41 44 18 40 43 23 41 43 28 40 40 32 40 42 50 40 42 5.00 40 41 02 37 35 05 22 26 09 37 40 13 40 42 17 42 43 The circulating fluids were supplied to the Temp. liPart at the time mentioned on the same line Cent. in first column. On caffeinized blood one minute. On caffeinized blood two minutes. On caflFeinized blood (0.4 : 300 c.c.) 1 min. On caffeinized blood (0.4:300 c.c.) 1 min. On caffeinized blood, as above, 2 minutes. On caffeinized blood, as above, 3 minutes. On caffeinized blood (0.6 :300 c.c.) 3 min. On caffeinized.blood (0.6 :300 c.c.) 5 min. Experiment discontinued. During the whole lengtli of the preceding experiment the regular rhythmical sequence in tlie contractions of the heart never varied from its normal standard ; it was perfect and vigorous. The influence of caf- feine in relatively small doses upon the rate, is, I think, well sliown. It decidedly increases the rate of beat at the same time that it renders the contractions stronger and increases the work done, and it was only when very strongly caffeinized blood was used for a longer space of time than in tiie previous observations that the rate and work went down. During this time the heart's action became somewhat sluggish, the auricles were larger than normal, contracting imperfectly, the ventricle contracted peri- staltically and incompletely. The entire heart, however, quickly recovered under normal blood. From this experiment it is further concluded that caffeine possesses a slight cumulative action.](https://iiif.wellcomecollection.org/image/b22299725_0030.jp2/full/800%2C/0/default.jpg)
