Genetic control of natural resistance to infection and malignancy / edited by Emil Skamene, Patricia A.L. Kongshavn, Maurice Landy.

  • International Symposium on the Genetic Control of Natural Resistance to Infection and Malignancy (1980 : Montréal, Québec)
Date:
1980
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: Genetic control of natural resistance to infection and malignancy / edited by Emil Skamene, Patricia A.L. Kongshavn, Maurice Landy. Source: Wellcome Collection.

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    STUDIES ON THE GENETIC CONTROL OF VISCERAL LEISHMANIASIS IN BALB/c MICE BY L.TROPICA F.Z. Modabber^, M. Alimohammadian, A. Khamesipour, M.H. Pourmand, M. Kamali and M. Nasseri^ Department of Pathobiology, School of Public Health, Tehran University, Tehran, Iran and Department of Microbiology, Harvard School of Public Health Boston, Mass. ^Present address (for all communications): Experimental Immunotherapy, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris cedex 15, France. 2 Present address: Dept. of Microbiology and Immunology Center for Health Sciences, U.C.L.A., Calif. 90024. INTRODUCTION Injection of an infective dose of Leishmania tropica to different strains of mice produces various forms of leish¬ maniasis (1). Some strains recover from the infection (healers) and others retain a persistent lesion (nonheal- ers). Healer strains may become nonhealer when injected with higher doses of the organism (2,10). We observed that the injection of 1-2x10 promastigotes of L.tropica major produced a visceral and lethal infection with metastatic lesions in BALB/c mice (9). Weintraxib and Weinbaum (15), Smrkovski and Larson (13), and Bjorvatn and Neva (3) have also reported the same in BALB/c mice. The visceral disease in the BALB/c seems to be independent of the infective dose and the mice can not produce a strong DH reaction to leish- manin (2x10^ phenolized organisms) during the course of in¬ fection. Other strains of mice (A/J, C57BL/6,, C3H, CBA, AKR/Cu) similarly infected recovered from the infection and mounted a DH reaction (8). It therefore seemed that DH and susceptibility to visceral leishmaniasis in mice are inter¬ related and genetically controlled. Bradley and colleagues have analyzed the genetics of innate susceptibility of mice to L.donovani (4,5,6, this volume). In this system, the line between susceptible and resistant traits is very clear. The gene responsible for the susceptibility was shown to be located on chromosome 1 and was designated Lsh. Handman et al. ( 7 ) and Behin et al. ( 2 ) have shown a correlation between the growth of L.tropica in macrophages GENETIC CONTROL OF NATURAL RESISTANCE TO INFECTION AND MALIGNANCY 29 Copyright e 1980 by Academic Press, Inc. All rights of reproduction in any form reserved. ISBN 0-12-647680-2