Genetic control of natural resistance to infection and malignancy / edited by Emil Skamene, Patricia A.L. Kongshavn, Maurice Landy.

  • International Symposium on the Genetic Control of Natural Resistance to Infection and Malignancy (1980 : Montréal, Québec)
Date:
1980
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: Genetic control of natural resistance to infection and malignancy / edited by Emil Skamene, Patricia A.L. Kongshavn, Maurice Landy. Source: Wellcome Collection.

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    Macrophage in Genetic Resistance to Listeria 573 Inflammatory response (in vivo) in individual backcross, F]^ and parental mice was then studied and expressed as a per¬ cent of the mean response of BIO.A mice. The mean macro¬ phage inflammatory response of A/J mice was 37 ± 2%. The upper limit of low macrophage inflammatory responses char¬ acteristic of A/J mice was chosen as 63% (jj ± 2SD of A/J response) . Using this criteria to distinguish high and low responders 14 of 33 (42%) A/J x F]^ backcross mice showed high macrophage inflammatory responses. More than 90% of В10.A xFi backcross mice exhibited high macrophage inflamm¬ atory responses. Analysis of individual hybrid Fj^ and back- cross mice therefore suggested that the trait of enhanced macrophage inflammatory responsiveness is controlled by a single dominant gene thus resembling inheritance of resist¬ ance to Listeria monocytogenes. 1 *** Î40 - I 120 • 100 - z о Q. z < rl T •f: t. il B10.A A (eiO.AxA)F, BIO.AxF, AxF , Figure 5. Macrophage inflammatory response: backcross analysis.