The action of adrenalin and ergotamine on the uterus of the rabbit / by J.H. Gaddum.

  • John Gaddum
Date:
[1926?]
Catalogue details

Licence: In copyright

Credit: The action of adrenalin and ergotamine on the uterus of the rabbit / by J.H. Gaddum. Source: Wellcome Collection.

    10/16 (page 148)
    The series of such curves obtained by taking different values of the adrenalin proportion are similar in general shape to those published by Sollman(T). Fig. 8. Effect of varying both the concentration of ergotamine and the time it was left in the bath with different parts of the same uterus. While the present paper has been in preparation Braun(8) has pub¬ lished a study of the action of adrenalin and ergot alkaloids on rabbit’s uterus in which he makes the statement that the product of the concen¬ tration of ergot necessary to produce a given effect and the time it is left in the bath is constant. This would give a rectangular hyperbola as the curve connecting the two quantities. It is quite possible that Sollmann’s curves and mine are rectangular hyperbolse. An attempt was made to demonstrate the disappearance of ergota¬ mine from the bath by allowing it to act on one portion of muscle and then transferring the Ringer to another bath in which was a fresh bit of muscle. The second piece was paralysed to the same extent as the first, no measurable quantity of ergotamine having disappeared. Thus the amount of ergotamine passing into the muscle is de¬ pendent on: (1) The concentration of ergotamine in the bath. (2) The time the muscle is in the ergotamine. Ergotamine appears to continue to pass in for over 20 minutes in some cases. (3) The temperature. Two corresponding halves were tested with adrenalin and then placed in ergotamine for 5 minutes—one at 37° and the other at 5°-2°. The muscles were then replaced in their baths and re-tested. The former was more paralysed than the latter. It is independent of: (1) The bubbling of oxygen. Two corresponding halves were tested with adrenalin and then paralysed by being left in contact with ergotamine for 15 minutes. In one the oxygen was left bubbling all the time and in the other it was turned off after 2 minutes.