Transplantation genetics of primates / editors Hans Balner, Jon J. van Rood.

Date:
[1972]
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: Transplantation genetics of primates / editors Hans Balner, Jon J. van Rood. Source: Wellcome Collection.

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    CYTOTOXICITY REACTIONS 67 TABLE 2. Chi-Square Values Between Chimpanzee Antlsera Which Defined Antigen Groups In a Human Population Croup A [New] Jac 4 Jac 7 Larr 11/4/68 Larr 10/18/68 45 31 26 Jac 4 46 37 Jac 7 23 Group В [Long HL-A 2] Jonl 3/27/70 Lucy 2/16/70 Gina 7/68 Gina 11/5 Jonl 3/28/69 Lala 3/28/69 Bogam 2/17/69 Jonl 2/9/70 Jonl W Gina 2/16/70 31 43 40 39 20 20 22 13 15 Jon! 3/27/70 19 28 29 30 14 8 26 32 Lucy 2/16/70 39 38 11 15 15 7 5 Gina 7/68 58 21 24 19 15 19 Gina 11/5 21 24 16 15 21 Joni 3/28/69 12 3 22 28 Lala 3/28/69 0 6 12 Bogam 2/17/69 3 4 Joni 2/9/70 24 Group С [New] Group E [HL-A 11] Group G [Ao28] Wanda 2/9/70 Wanda 11/17/69 Abe 8 Wanda 11/17/69 Abe 8 Wanda 2/17 23 29 32 12 27 27 Ti 5 Di 3 Qu 2 Do 20 Lala 2/18/69 26 13 20 17 Ti 5 36 50 27 Di 3 46 19 Qu 2 29 Ao 28* Elgar 2/18/69 25 Group D [HL-A 2] Gina I Su 9/17/68 Su 9/17/68 42 Su Abs 25 30 Group F [New - LHE] LHe 20/5/68* Alice 8/6/70 20 Group H [4a] 4a* Peck 3/27/70 8 Peck 3/28/69 10 *Human Antiserum immunized with chimpanzee cells and it is possible that the anti-HL-A 11 reactivity of the 2/18/69 bleeding was produced in re¬ sponse to chimpanzee antigen. Since Bal- ner's Ti 5, an alloantiserum, also defined only HL-A 11, it seems possible that chim¬ panzees may have the HL-A 11 antigen or one that is very similar. Two antisera from chimpanzee Group I, Peck 3/27/70 and Peck 3/28/69, were cor¬ related with antigen 4a in our unrelated human panel and were designated as Group H. As was noted earlier, other antisera in chimpanzee Group I were not correlated with the human 4a antigen. Thus, the 4a antigen in man may be similar but not identical to the 4a found in chimpanzees. We did not find a correlation between Group IV (7c) antisera and HL-A 7 defined by human cytotoxic antisera, although such an association has been suggested,® nor was there a correlation found between human antigen 4b defined by human leukoagglu- tinating antisera and the one cytotoxic chimpanzee 4b related serum of Group III. Rather, Wanda 2/9/70 which defined Group III (4b) in chimpanzees was asso¬ ciated with human Group C. Recently, Metzgar and Miller reported producing a high titered cytotoxic 4b antiserum in a monkey by immunization with papain- soluble 4b antigen extracted from human spleen.'^ Characterization of the monkey 4b antiserum was done on the cell donors typed by van Rood. It will be interesting to see whether or not this monkey 4b anti¬ serum cross-reacts with chimpanzee cells. From the 56 families tested, two have been chosen for detailed presentation to illus¬ trate the results obtained with chimpanzee antisera. In the BER family (Table 3) four HL-A antigens in the first segregating series