A first study of the statistics of pulmonary tuberculosis / by Karl Pearson.

  • Pearson, Karl, 1857-1936.
Date:
1907
Catalogue details

Licence: In copyright

Credit: A first study of the statistics of pulmonary tuberculosis / by Karl Pearson. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    The tables have been worked out as fourfold tables of normal distribution, the assumption made of course being that the modal frequency of pulmonary tubercu- losis is not among the very slight or very severe cases. This is generally in accord- ance with Dr. Thompson’s statistics for degree of acuteness and of haemoptysis,* which, I think, suffice to show no clustering at one end of the range and justify the use of the fourfold table method for approximate results, and will provide at any rate a first approximation, which is all we can venture to hope for at present, to the intensity of tuberculous heredity. For the male pedigrees, the equation for the correlation coefficient is L044,264 = r + 1 155,432 r2 + -241,046 r3 - -032,869 D which gives in the nearest second decimal : r = -59. For the female pedigrees, the equation for the correlation coefficient is 1-091,844 = r + 1 072,139 r2 + -192,622 r3 + -024,362 r4 which gives to the nearest second decimal: /• = ‘62. Thus while the male pedigrees give a slightly lower intensity of inheritance than the female, both practically give 6 for the value of the coefficient of parental heredity. Before drawing any conclusion, I will endeavour to ascertain the effect of modifying the values of x and y. Clearly a lower limit to the intensity would be found by putting y = o. This gives :— Male Pedigrees. Parent. Female Pedigrees. Parent. T. N.T. Totals. T. N.T. Totals. T. 49 361 410 T 107 509 616 N.T 108 3,582 3,690 N.T 207 5,337 5,544 Totals 157 3,943 4,100 Totals 314 5,846 6,160 * Log. cit., pp. 52, 53, 62, 63. He gives the following data :— 0 Acquired Phthisis. Hereditary Phthisis. Males (1,000). Females (1,000). Males- (1,000). Females (1,000). 1 i fAcute 288 425 320 445 '3 £ - Sub-acute 441 326 382 296 q q 1 Chronic 271 249 298 259 g 1 Copious 279 170 272 180 o'.® 1 Moderate 146 116 171 144 | Slight 306 368 285 344 W (Nil 269 346 272 332