The constituents of olive bark / by Frederick B. Power and Frank Tutin.
- Frederick Belding Power
- Date:
- [1908]
Licence: Attribution 4.0 International (CC BY 4.0)
Credit: The constituents of olive bark / by Frederick B. Power and Frank Tutin. Source: Wellcome Collection.
Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.
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![61‘5 per cent, was soluble in cold water. A further 32-3 per cent, could bo dissolved by boiling water, but separated on cooling, whilst the remainder amounting to about 6-2 per cent., was quite insoluble in either cold or4iot water. The portion of the alcoholic extract which was dissolved by cold water contained an amount of c?-mannitol equivalent to nearly 1‘9 per cent, of the weight of air-dried bark, together with tannic matter, viscid, brown products, and a sugar which yields (Z-phenylglucosazone. It also contained a small amount of a new, crystalline phenolic substance, olenitol, (m. p. 265°), dilute solutions of which show a blue fluorescence. Acetylolenitol melts at 130°. The portion of the alcoholic extract which was soluble in hot but not in cold water consisted for the most part of brown, resinous products, some of which yielded glucose on hydrolysis, but a small amount of olenitol was also obtained from them. The material insoluble in water consisted chiefly of a mixture of new monocarhoxylic acids, all of which crystallise from ethyl acetate in small leaflets. They have the following composition and properties : (1) an acid, Cg^Hgi^’COgH (m. p. 69—70°), which yields an ethyl ester melting at 63°; (2) an acid, C24H45*C02H (m. p, 79°), the ethyl ester of which melts at 66'5°. Both of these acids are soluble in petroleum (b. p. 35—50°); (3) an acid, C34Hgg*C02H (m. p. 92°), which is insoluble in petroleum, and yields an ethyl ester melting at 87°; (4) an acid, C29Hg7‘002H (m. p. 84°), which yields an ethyl ester melting at 75°, and, like the preceding one, is insoluble in light petroleum. In addition to these acids, a substance, probably a tertiary alcohol, CggHggO (m. p. 70°), was obtained, together with a small amount of pentatriacontane, (m. p. 74—75°), a phytosterol, C27H4gO (m. p. 136°; [a]i, - 35'2°), the acetate of which melts at 119‘5°, and a very small amount of a substance, C23Hgg02(0H)2 {m. p. 285—290°), which yields an acetyl derivative, C23Hgg04(C0*CHg)2, melting at 160°. This last-mentioned substance is identical with a compound which has recently been isolated by Power and Rogerson from Ipomoea purpurea, and designated ipuranol. In conclusion it may be noted that the constituents of olive bark are quite dissimilar to those of the leaves, as our investigations have shown that only three substances are common to both, namely, ci-mannitol, sugar, and pentatriacontane. In view of the large percentage of fatty oil contained in the ripe fruit of the olive tree, it may also be considered remarkable that the bark should be devoid of even traces of the ordinary fatty acids. Thb Wellcome Chemical Keseakch Labohatohies, London, E.C.](https://iiif.wellcomecollection.org/image/b22425305_0018.jp2/full/800%2C/0/default.jpg)
