Distribution of histamine and substance P in the wall of the dog's digestive tract / by W.W. Douglas [and others].

Date:
[1951?]
Catalogue details

Licence: In copyright

Credit: Distribution of histamine and substance P in the wall of the dog's digestive tract / by W.W. Douglas [and others]. Source: Wellcome Collection.

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    85 % of the histamine of the stomach wall was accounted for by that present in mucosa and submucosa. In all parts of the stomach the histamine equivalent of the m. externa was low, the lowest values being obtained in the pyloric region, although here the m. externa may form about two-thirds of the wall. These results are in agreement with those of Gavin et al. (1933). In Expt. 3, two pieces were taken from the corpus of the stomach, one along the greater curvature, the other, opposite to it, along the lesser curvature. The piece from the lesser curvature contained more histamine than that from the greater curvature; the difference was shared by all layers but it was not great (see Table 2). Table 3. Histamine equivalent of wall of intestine /xg. histamine/g. in Contribution of each layer to wall Area Individual layers % weight of tissue % weight of histamine in Expt. Whole ,-A-——-•, t-A— -a Fig. 1 no. wall GM. MM. SM. ME. GM. MM. SM. ME. GM. MM. SM. ME 1 85 100 115 87 42 20 36 12 32 24 48 12 16 6 2 117 85 155 80 41 24 35 13 28 17 64 9 10 3 79 68 117 70 37 24 39 11 26 20 58 10 12 1 86 105 115 85 34 23 37 10 30 28 50 10 12 7 2 89 90 150 50 46 24 32 10 30 24 54 6 16 3 83 77 117 73 37 25 40 10 25 23 57 9 11 1 73 95 100 55 27 29 31 9 31 38 43 7 12 8 2 72 90 140 36 24 30 23 10 37 38 45 5 12 3 99 97 190 70 26 29 29 10 32 29 56 7 8 9 3 66 77 93 55 22 25 38 9 28 29 54 8 9 1 70 100 90 55 27 22 38 10 30 31 49 8 12 10 2 77 70 160 34 30 25 28 10 37 23 60 3 14 3 68 80 100 60 24 23-5 36 9-5 31 28 53 8 11 11 3 68 65 125 43 20 17-5 35 12-5 35 17 65 8 11 12 3 57 38 103 28 18 19 36 11 34 13 71 5 11 1 67 60 130 48 20 30 29 9 32 27 57 7 9 13 2 63 50 180 22 39 33 16 10 41 26 45 4 25 3 48 16 80 23 13 12 48 12 28 5 79 6 10 1 53 50 100 40 18 9 35 14 42 9 67 10 14 14 2 49 23 145 25 25 25 20 13 42 12 60 7 21 3 49 29 87 30 19 10 40 15 35 6 71 9 14 1 55 11 180 34 r 5 25 16 54 1 82 10 7 15 2 32 11 115 22 6 10 20 20 50 3 73 14 10 3 46 5 135 32 7 6 27 18 49 1 79 7 13 1 48 9 160 38 10 5 22 16 57 1 74 13 12 16 2 37 5 100 24 18 8 22 26 44 1 60 17 22 GM=glandularis mucosae; MM.=muscularis mucosae; SM.=submucosa; ME.=muscularis externa. Small intestine. As seen from Fig. 1, the wall of the small intestine has u a high histamine equivalent which gradually decreases from duodenum to :: ileum and, in the duodenum, the histamine equivalent is even higher than that of the stomach wall of the fundus or corpus. Again, as can be seen from Table 3, 8 the main contribution of histamine is made from the mucosa, and again if relatively high values are obtained from the submucosa, whereas the m. Jr externa usually contains less histamine. This layer contributes only between l 8 and 25% (average 12%) to the histamine of the wall, although it represents ; 25-42% (average 33%) of its weight. The highest values (up to 190pg./g.) . were obtained from the m. mucosae, which in all but one piece yielded higher I