An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)
    

concept

The suppression of experimental allergic encephalomyelitis and multiple sclerosis / [based on the proceedings of the Liversedge Symposium, held under the auspices of the Multiple Sclerosis Society on 15 October, 1979] ; edited by A.N. Davison and M.L. Cuzner.

Experimental allergic encephalomyelitis and the "auto-allergic" diseases / by Byron H. Waksman.

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Encephalomyelitis, Autoimmune, Experimental

Catalogue

The suppression of experimental allergic encephalomyelitis and multiple sclerosis / [based on the proceedings of the Liversedge Symposium, held under the auspices of the Multiple Sclerosis Society on 15 October, 1979] ; edited by A.N. Davison and M.L. Cuzner.

Experimental allergic encephalomyelitis and the "auto-allergic" diseases / by Byron H. Waksman.