Small proteinaceous infectious particles which resist inactivation by procedures that modify NUCLEIC ACIDS and contain an abnormal isoform of a cellular protein which is a major and necessary component. The abnormal (scrapie) isoform is PrPSc (PRPSC PROTEINS) and the cellular isoform PrPC (PRPC PROTEINS). The primary amino acid sequence of the two isoforms is identical. Human diseases caused by prions include CREUTZFELDT-JAKOB SYNDROME; GERSTMANN-STRAUSSLER SYNDROME; and INSOMNIA, FATAL FAMILIAL.
    

concept

Fatal flaws : how a misfolded protein baffled scientists and changed the way we look at the brain / Jay Ingram.

Infectious processes : knowledge, discourse, and the politics of prions / edited by Eve Seguin.

The human body: how we fail, how we heal. Part 1.

Prions, prions, prions / edited by S.B. Prusiner.

Novel infectious agents and the central nervous system.

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Prions

Catalogue

Fatal flaws : how a misfolded protein baffled scientists and changed the way we look at the brain / Jay Ingram.

Infectious processes : knowledge, discourse, and the politics of prions / edited by Eve Seguin.

The human body: how we fail, how we heal. Part 1.

Prions, prions, prions / edited by S.B. Prusiner.

Novel infectious agents and the central nervous system.