An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.
    

concept

The stability and solubility of diphtheria toxin in acid and alkili / Una Wallace.

The measurement of the combining power of diphtheria toxin and toxoid with anti-toxin in relation to their antigenic efficacy / by A.T. Glenny, C.G. Pope, and Hilda Waddington.

On the power of the liver to destroy diphtheria toxin / by Sir Lauder Brunton and T.J. Bokenham.

The antigenic effect of intravenous injection of diphtheria toxin / by A.T. Glenny and C.G. Pope.

The titration of diphtheria toxin by the flocculation method / A.T. Glenny and U. Wallace.

Galleries and Reading Room

Library

Shop

Café

'1880 THAT' is temporarily closed while we carry out some work on the exhibition. We'll reopen as soon as possible.

We're running paid user research studies to improve Wellcome Collection online

Diphtheria Toxin

Catalogue

The stability and solubility of diphtheria toxin in acid and alkili / Una Wallace.

The measurement of the combining power of diphtheria toxin and toxoid with anti-toxin in relation to their antigenic efficacy / by A.T. Glenny, C.G. Pope, and Hilda Waddington.

On the power of the liver to destroy diphtheria toxin / by Sir Lauder Brunton and T.J. Bokenham.

The antigenic effect of intravenous injection of diphtheria toxin / by A.T. Glenny and C.G. Pope.

The titration of diphtheria toxin by the flocculation method / A.T. Glenny and U. Wallace.