A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
    

concept

Huntington's chorea pedigree, constructed from

On Huntington's chorea / [John Michell Clarke].

Chorea.

Affective disorders : current research aspects and psychiatry and old age : proceedings of the scientific meetings accompanying the 52nd and 53rd Beattie-Smith lectures, University of Melbourne / edited by Graham D. Burrows.

Huntington Disease

Images

Catalogue

On Huntington's chorea / [John Michell Clarke].

Chorea.

Affective disorders : current research aspects and psychiatry and old age : proceedings of the scientific meetings accompanying the 52nd and 53rd Beattie-Smith lectures, University of Melbourne / edited by Graham D. Burrows.

The gene code. Part 1, The code of life and. Part 2, Unlocking our code.

Function and dysfunction in the basal ganglia / edited by A.J. Franks [and others].