A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, i.e., DNA FRAGMENTATION.  It is genetically programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
    

concept

Apoptotic cells

Apoptosis in an isolated ovarian follicle

Focus of plasma cell apoptosis

Apoptosing plasma cells and collagen

Apoptotic cells in a mouse blastocyst

Apoptosis, past and future / John Kerr.

Programmed cell death in animals and plants / edited by J.A. Bryant, S.G. Hughes, and J.M. Garland.

A critical review of apoptosis in historical perspective / Marcella Malmusi, A. Bernard Ackerman.

Sex and the origins of death / by William R. Clark.

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Apoptosis

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Catalogue

Apoptosis, past and future / John Kerr.

Apoptotic cells in a mouse blastocyst

Programmed cell death in animals and plants / edited by J.A. Bryant, S.G. Hughes, and J.M. Garland.

A critical review of apoptosis in historical perspective / Marcella Malmusi, A. Bernard Ackerman.

Sex and the origins of death / by William R. Clark.