Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
    

concept

Anesthetics, Local

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Catalogue

Butyn.

Local anesthetics : mechanisms of action and clinical use / Benjamin G. Covino and Helen G. Vassallo.

Der Kampf gegen den Schmerz bei operativen Eingriffen ... : mit besonderer beziehung auf die Zahnheilkunde / [Johannes Wolfram].

Modern treatment; anaesthesia / by W. Stanley Sykes ... with a section on local anaesthesia, by P. J. Moir.

Quinine-Urea-Hydrochloride as a local anaesthetic and as a dressing for infected wounds.