A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.
    

concept

THT : the AIDS gestapo / Gays Against Genocide.

Cuts or no cuts... : ...we'll still be providing services ... making informed choices, the Trust's position regarding Zidovudine (AZT) / The Terrence Higgins Trust.

Gays Against Genocide ... : sack Nick the Sick now / Gays Against Genocide.

"I've been taking AZT, 3TC and NVP for almost 4 years. I'm healthy and happy." / City of Cape Town, Medicins sans frontiers.

Trizivir zidovudine / lamivudine / abacavir / Actions Traitements.

Retrovir introduction at Dartford.

We were here : San Francisco's year zero.

AIDS trust rethink on AZT : Catherine Pepinster on why the Terrence Higgins Trust is changing its drug advice.

AZT on trial : an all day conference exposing the practices in the development, licensing and prescription of AZT / SCAM.

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Trizivir zidovudine / lamivudine / abacavir / Actions Traitements.

Retrovir introduction at Dartford.

We were here : San Francisco's year zero.

AIDS trust rethink on AZT : Catherine Pepinster on why the Terrence Higgins Trust is changing its drug advice.

AZT on trial : an all day conference exposing the practices in the development, licensing and prescription of AZT / SCAM.