Regions of AMINO ACID SEQUENCE similarity in the SRC-FAMILY TYROSINE KINASES that fold into specific functional tertiary structures. The SH1 domain is a CATALYTIC DOMAIN. SH2 and SH3 domains are protein interaction domains. SH2 usually binds PHOSPHOTYROSINE-containing proteins and SH3 interacts with CYTOSKELETAL PROTEINS.
    

concept

Molecular model of SH3 domain, CPK model.

Molecular model of SH2 domain (adaptors)

Molecular model of SH3 domain showing peptidic

Stick molecular model of SH3 domain

Diagram of SH2 domain (adaptor)

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Src Homology Domains

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Catalogue

Diagram of SH2 domain (adaptor)

Stick molecular model of SH3 domain

Molecular model of SH3 domain showing peptidic

Molecular model of SH3 domain showing peptidic

Molecular model of SH2 domain (adaptors)