A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
    

concept

Treatment options in addiction : medical management of alcohol and opiate abuse / edited by Colin Brewer.

Disulfiram

Catalogue

Treatment options in addiction : medical management of alcohol and opiate abuse / edited by Colin Brewer.

A drug sensitising the organism to ethyl alcohol / Jens Hald, Erik Jacobsen.