An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
    

concept

Ueber ein Anticholeraserum / von Allan Macfadyen, M.D., London.

A study of vibrio filtrates / by Richard W. Linton, Harwant Singh and S.C. Seal.

Advances in research on cholera and related diseases : Tokyo, August 22-23, 1972 and Round Table Discussions on International Quarantine against Cholera, Aso National Park, Kumamoto, August 20, 1972 / edited by Hideo Fukuki and Makoto Ohashi.

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Cholera Toxin

Catalogue

Ueber ein Anticholeraserum / von Allan Macfadyen, M.D., London.

A study of vibrio filtrates / by Richard W. Linton, Harwant Singh and S.C. Seal.

Advances in research on cholera and related diseases : Tokyo, August 22-23, 1972 and Round Table Discussions on International Quarantine against Cholera, Aso National Park, Kumamoto, August 20, 1972 / edited by Hideo Fukuki and Makoto Ohashi.