Quinine prophylaxis and latent malaria infection / by I.J. Kligler.

  • Israel Jacob Kligler
Date:
1923
Catalogue details

Licence: Public Domain Mark

Credit: Quinine prophylaxis and latent malaria infection / by I.J. Kligler. Source: Wellcome Collection.

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    period. At the same time, active petrolisation was started. ‘he swamps, however, were so extensive, and breeding so active, that complete mos- quito control was not achieved. The breeding of mosquitoes was greatly reduced, but adult mosquitoes were found on every inspection. The first results of the control measures were excellent. ‘he cases dropped rapidly and were kept under control until December 15th, when the bulk of the men were dismissed. The results are shown in the following table :— MALARIA INCIDENCE IN ATHLIT. No. of men. No. of cases. Per cent. Incidence. Days lost. July ... ag 80 39 50 815 August ee 150 43 30 262 September... 200 20 10 132 October ae 2.00 i) 6°5 105 November .... 200 23 dels 125 The figures given in the table show good results, but there is another side of this picture which is not so pleasing. Prior to the dispersal of the men, quinine distribution was stopped for four days and the blood of 112 men examined. ‘Thirty parasite carriers were found in these 112 men; twenty-seven malignant tertian and three benign tertian, four of them with gametes. In other words, there were at least 26°8 per cent. parasite carriers in the camp. The greater number of these men were dispersed to various parts of the country before intensive treatment could be carried out. Each of the thirty parasite carriers thus became a new focus for the dissemination of malaria. About sixty men remained behind at Athht. Quinine prophylaxis was stopped in order to give the men a chance to receive malaria attacks and proper treatment. ‘The number of relapses during the months of December, January, February and March totalled fifty-one; about 75 per cent. of the men relapsed once, and 10 per cent. had two or three relapses. The conclusion from the results presented above is good or bad according to the view point. 1. From the public health standpoint the effect of the quinine was decidedly harmful. By maintaining a condition of latent infection there is a large increase in the number of carriers, and also in the number of cases of chronic malaria extremely resistant to treatment.
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