Additive compounds of antipyrylaminodiacetic acid and its salts with neutral salts / by Robert George Fargher and Harold King.

  • Fargher, Robert George.
Date:
1921.]
Catalogue details

Licence: Public Domain Mark

Credit: Additive compounds of antipyrylaminodiacetic acid and its salts with neutral salts / by Robert George Fargher and Harold King. Source: Wellcome Collection.

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    XXXVIII.—Additive Compounds of Antipyrylamino- diacetic Acid and its Salts with Neutral Salts. By Robert George Fargher and Harold King. The capacity of the weakly basic substance antipyrine to form additive compounds with very varied organic substances, generally containing oxygen, and with metallic salts of organic and inorganic acids, has often come to light in attempts to explain its incom¬ patibility in pharmacy and to modify or supplement its action in therapeutics. Apart from two compounds with calcium chloride, (CnH120N2)3,CaCl2,12H20 and (C11H12QN2)3,2GaCl2,9H20, described by Pfeiffer and Wittka (Ber., 1915, 48, 1289), no complexes are known with the haloids of the alkali or alkaline earth metals. A simple derivative of antipyrine. antipyryl-4-aminodiacetic acid (D.R.-P. 144393), MeC—C-N< MeN io CHj-COjH CH,-CO»H has been found by the authors to furnish an unusually interesting series of simply molecular, additive compounds with the haloids of the alkali and alkaline earth metals. Though the salts of this acid are dismissed in the original specification with the statement that the barium salt was obtained only as a hard, dry mass, the authors have found that the calcium, strontium, and barium salts are well-defined, crystalline substances containing various propor¬ tions of water of crystallisation, and have isolated, but with greater difficulty, crj'stalline sodium and potassium salts. Additive compounds of two molecules of the acid with one of calcium chloride, calcium bromide, or strontium chloride, and of one molecule of the acid with one of sodium, lithium, or potassium chloride, have been prepared, but the analogous compounds from magnesium or barium chloride were not obtained. The combining powrer is, moreover, retained by the calcium, strontium, barium, and magnesium salts of the acid, two molecules of the salt uniting with one of the corresponding metallic chloride. The mode of preparation of these complexes is sufficiertly indicated in the experimental portion of the paper. Attention