Northwestern University, Evanston

Date:: 1966

Reference:: PP/CRI/E/1/15/3

Catalogue details

Licence: In copyright

Credit: Northwestern University, Evanston. Source: Wellcome Collection.

4/12

2nd December I966. Dr Hans Noll, Northwestern University, Department of Biological Sciences, Evan3ton, Illinois 60201, U.S.A. Dear Hans, I think we had better make it Tuesday 24th January. I may have to call in at Harvard on the way and I could conveniently do this at the week-end before I visit you. Whatever is decided at the Salk Institute I think it is most unlikely that I should have to change this date. Don't forget to let me know about the title for the lecture. We have done practically nothing on chain initiation in mammalian cells but are not surprised to learn that it is not N-Pormylmethionine- tRNA. I was most interested to read about three classes of ribosomes and especially appreciated your point that one might be able to distinguís between them by the use of different inhibitors. The main news here is that Howard Goodman has shown that the alteration to the tRNA in the tyrosine suppressor is, as expected, in the anticodon, GUA being changed to GUA. As to UGA we are pretty certain that it is nonsense but we do not know yet what it does. With all good wishes, F.H.C. Crick.