A process for preparing a medicinal compound containing mercury compounds and other substances / [Julius Rother].

  • Rother, Julius.
Date:
1902
Catalogue details

Licence: Public Domain Mark

Credit: A process for preparing a medicinal compound containing mercury compounds and other substances / [Julius Rother]. Source: Wellcome Collection.

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    N° 21,295 Al.D. 1901 Date of Application, 23rd Oct., 1901—Accepted, 8th May, 1902 5 10 15 COMPLETE SPECIFICATION. A Process for Preparing a Medicinal Compound containing Mercury Compounds and other Substances I, Julius Pother, of Katscher, Upper Silesia, in the Empire of Germany, Doctor of Medicine, do hereby declare the nature of mv invention and in what manner the same is to be performed, to be particularly described and ascertained in and by the following statement: — The present invention consists of a process for producing a powder from alsol, sublimate sozoiodol-quicksilver and veratrine. In carrying out the process 9 parts by weight of alsol (aluminium acetico tartaricum) are first dissolved in distilled water with an addition of alcohol, only just sufficient solution being employed as is necessary to effect solution. To this mixture is added one half part by weight of chloride of mercury called sublimate (hydrargyrum bieloridum), with the addition of a little common salt also dissolved in diluted alcohol and then one half part by weight of mercury sozoiodol (hydrargyrum sozoiodolicum). The latter is advantageously mixed in a dry state with the common salt (about half the amount) thoroughly shaken and then a sufficient quantity of from JO to 40° alcohol poured on to the mixture and the whole thoroughly dissolved by being warmed. For each gramme of these 10 parts by weight, 0,014 grammes of veratrine (veratrinum Merck) is added. The veratrine is also dissolved in a corresponding quantity of alcohol and then added to the mixture. Any dullness or precipitation which takes place as the whole solution cools 20 down, will disappear immediately it is warmed again. The whole mixture is now vaporized down to a thick fluid consistency in a water bath, which should not be too strongly heated, it is then dried in a moderate heat and suitably ground or otherwise reduced to a powder. The powder is of a light yellowish color and somewhat hygroscopic. ^5 The powder thus obtained forms, if rubbed or ground down together with lactose in the proportion of 1:500 an excellent preventative and healing medium for diseases of the nose, mouth and throat, in that it may be applied to the diseased tissues direct bv means of a blower. t/ Alsol (aluminium acetico-tartaricum solubile) is a non-poisonous astringent 30 and antiseptic and serves as a substitute for the solution of acetate of alumina (liquor aluminis acetici). Alsol dissolves slowly in water. Mercury sozoiodol (hydrargyrum sozoiodoficu'm) is employed similarly to corrosive sublimate but only contains about 33% of mercury. It is insoluble in water and soluble in dilute mercurv. «/ 25 Veratrinum is an amorphous alkaloid obtained from the seed of Sabadilla officinarum melanthaceae and put on the market by the firm of Merck at Darm¬ stadt. It is insoluble in water, soluble in alcohol. By sublimate, sublimate of mercury (bichloride of mercury) is intended. It is not easily soluble in water but easily soluble in alcohol. 40 The new preparation dissolves in water as easily and rapidly as common salt. Of its constituents, only the weight of those is stated the curative effect of which comes into question. By themselves, bichloride of mercury, mercury sozojodol and veratrinum are highly poisonous. It wTas therefore necessary to discover a form in which their curative effect would be as powerful and certain as their 45 complete innocuousness, so that poisonous effects wmuld be impossible. The [Price 8<f.]