Improvements in the manufacture and production of a pharmaceutical compound.

  • Farbenfabriken vormals Freidrich Bayer & Co.
Date:
1905
Catalogue details

Licence: Public Domain Mark

Credit: Improvements in the manufacture and production of a pharmaceutical compound. Source: Wellcome Collection.

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    Improvements in the Manufacture and Production of a Pharmaceutical Compound. The metatolylsemicarbazide thus obtained deposits on cooling. It is filtered off and purified by a recrystallization from water. The process proceeds in an analogous manner on using salts of other imidoethers of the meta-tolylhydrazine carboxylic acid. Example C. One part of the imido chloride of metatolylhydrazine carboxylic acid (obtainable by the action of hydrochloric acid gas on the nitrile of the metatolylhydrazine carboxylic acid dissolved in ether) is mixed with 25 parts of water. On heating, the reaction takes place according to the following equation : NH 10 CH.-C-Hi-NH-NH-C + H20=CH3-CgH4-NH- NH-CONH2 +HC1 The metatolylsemicarbazide thus precipitated is filtered off and recrystallized from water. Example D. - A mixture of 20 parts of a 20 per cent solution of barium hydroxide, 50 parts of 15 water and 10 parts of the hydrochloride of the amidine of metatolylhydrazine carboxylic acid is heated to 120° for several hours. The reaction takes place according to the following equation : CH3-GYEI4-NH + HaO—NHgH-CHg — C6H4 -NH - NH 2 - conh3 The metatolylsemicarbazide thus obtained is filtered off and rocrystallized from 20 water. Example E. A mixture of 10 parts of metatolylazocarbonamide (M.Pt. 72—74° orange-red crystals) 200 parts of water, 5 parts of acetic acid and 5 parts of zinc dust is heated until the mass becomes uncolored. The metatolylsemicarbazide thus obtained is 25 then filtered off and recrystallized from water. The hydrochloride of the amidine of metatolylhydrazine carboxylic acid men¬ tioned in Example D can be prepared on heating an alcoholic solution of cyanamide with the hydrochloride of metatolylhydrazine. My foreign correspondents do not intend to confine themselves to the particulars 30 given in the above examples which are merely typical and can be varied within wide limits without altering thereby the nature of the above invention. Dated this 31st day of August, 1904. NEWTON & SON 6 Breams Buildings, Chancery Lane, London, E.C. Agents for the Applicant.
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