Improvements in the manufacture and production of a pharmaceutical compound.

  • Farbenfabriken vormals Freidrich Bayer & Co.
Date:
1905
Catalogue details

Licence: Public Domain Mark

Credit: Improvements in the manufacture and production of a pharmaceutical compound. Source: Wellcome Collection.

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    Improvements in the Manufacture and Production of a Pharmaceutical Compound' COMPLETE SPECIFICATION. “Improvements in the Manufacture and Production of a Pharmaceutical Compound,” I, Henry Edward Newton, of the Office for Patents, 6 Breams Buildings, Chancery Lane, in the County of London, Patent Agent, do hereby declare the nature of this invention and in what manner the same is to be performed, to be particularly described and ascertained in and by the following statement:— My foreign correspondents discovered some time since, that the meta-tolylsemi- 5 carbazide having the formula : CH3 NH-CONH. possesses valuable therapeutic, especially antipyretic, properties and that this pew compound can be obtained e.g. by treating meta-tolylhydrazine (CH3 — CeH* — NH —NH2) or salts thereof, with such derivatives of carbonic acid, (for instance urea, 10 urethanes, cyanic acid, or the like) by the employment of which the group — CO—NH‘2 can be introduced into the hydrazine molecule. My foreign correspondents have now found that the meta-tolylsemicarbazide of the above given formula can also be obtained on splitting off one molecule of halogen alkyl from the hitherto unknown salts of the imido ethers of the meta- 15 tolylhydrazine carboxylic acid having the formula : - — CH, / X, \/ NH—NH—C NH, H—halogen. \0—alkyl. by heating these bodies to higher temperatures or on transforming these salts into the metatolylsemicarbazide by treatment with water ; or on treating with water the hitherto unknown halogenimides of metatolylhydrazine carboxylic acid or on 20 treating with agents capable of splitting off ammonia the amidine of this acid, which compounds have the following general formula : CHS ! (■ ■ ■ - 1 / X ^ X1KH-NH —C = NH 1
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