The mechanism of action of adrenaline on the superior cervical ganglion of the cat / W.D.M. Paton and J.W. Thompson.

  • Paton, William D. M.
Date:
[1953?]
Catalogue details

Licence: In copyright

Credit: The mechanism of action of adrenaline on the superior cervical ganglion of the cat / W.D.M. Paton and J.W. Thompson. Source: Wellcome Collection.

    1/2
    XIX INTERNATIONAL PHYSIOLOGICAL CONGRESS P. 66b-5 1221 D.M.Paton and J•W•Thompson* Le mechanism of action of adrenaline on the super Lor rvical ganglion of tie cat* xperiments have been done on the mechanism whereby renaline interferes with transmission in the superior rvical ganglion of the cat anaesthetised with chloralose. 1 . Adrenaline injected intra-arterially into the nglion with an intact blood supply greatly reduces the nglion action potentials resorde between the ganglion and s postganglionis trunk* There is no accompanying de- larization of the ganglion. The shape of the action tential after ‘•'adrenaline did not resemble that seen temicotine or hexamethonium but corresponded to an en reduction of spike and after potential together. 2* The effect of adrenaline intra-arterially on btlycholine output from a superior cervical ganglion per- seel with eserinised Locke solution, and stimulated for nods of 3 min at 10/sec. through its preganglionic pnk was tested. The effluent was assayed on the dorsal scle of the leech, due allowance being made for the lsiti.zation which adrenaline produces on the responses the leech to acetylcholine. The output of acetylcholine m- the superior cervical ganglion was considerably Luced in the presence of adrenaline: e.g. 1 \ig adrenaline rered the output by 50/5. 3. Adrenaline antagonises the stimulant effect of itylcholine injected into the ganglion perfused with -eserinised Locke solution, roughly in parallel with reduction of ganglionic transmission. It was concluded that adrenaline interferes with gang- nic transmission in two ways:- by diminishing the release of acetylcholine in response preganglionic stimulation. by depressing the action of acetylcholine on the nglion cells. In its possession of these properties seems to resemble a drug such as procaine amide more osely than any other ganglionically active drug.