Studies on the etiology of blackwater fever / I.J. Kligler.

  • Israel Jacob Kligler
Date:
1923
Catalogue details

Licence: Public Domain Mark

Credit: Studies on the etiology of blackwater fever / I.J. Kligler. Source: Wellcome Collection.

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    EFFECT OF QUININE ON BLOOD CELLS FROM MALARIA AND BLACK- WATER FEVER PATIENTS AND FROM NORMAL INDIVIDUALS These experiments were a repetition of those made by Barratt and Yorke and confirmed their findings. Quinine had the same effect on normal and malarial blood. It required a concentration of 0.2 per cent of quinine hydrochloride to cause laking of each. In one series of tests only was the blood of a blackwater fever patient laked by a somewhat lower concentration (0.15 per cent) of quinine. But to attain even this concentration in the body, it would be necessary to inject into the circulation approximately 7 grams of quinine and maintain that concentration for some time. EFFECT OF BILE ON NORMAL, MALARIAL, AND BLACKWATER FEVER BLOOD CELLS Subacute jaundice was regularly present in the individuals prior to the attack of hemoglobinuria. The physicians of Palestine consider the jaundice as an indication of danger and refuse to give quinine to such patients. This fact, together with the known hemolytic power of bile, suggested that this substance might play some causative réle in hemoglobinuria. ‘Tests were made, therefore, on the effect of ox bile, on blood cells of normal individuals as well as of those suffering with malaria or blackwater fever. The results showed that bile in a dilution of 1:25 caused prompt laking of cells of healthy or diseased individuals, while a dilution of 1:50 usually did not lake the blood cells. In either dilution the effect was practically the same on various types of blood. EFFECT OF MIXTURE OF QUININE AND BILE Experiments were now made to ascertain the associative action of bile and quinine in various proportions. Interesting results were obtained. Mixtures containing a 1:50 or 1:75 dilution of bile and 0.02 to 0.03 per cent of quinine invariably brought about laking, while the same concentrations of these substances acting separately had no effect. In other words concentrations of bile and quinine, separately incapable of producing laking, caused
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