On the regulation of the blood-supply of the brain / by C. S. Roy and C. S. Sherrington.

  • Roy, C. S.
Date:
[1890]
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Credit: On the regulation of the blood-supply of the brain / by C. S. Roy and C. S. Sherrington. Source: Wellcome Collection.

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    [Frotu the Journal of Fliysiology. Vol. XL Nus, 1 d' 2, 1800.] ON THE REGULATION OF THE BLOOD-SUPPLY OF THE BRAIN. Br C. S. ROY, M.D, F.RS., Professor of Pathologij, University of Cambridge, AND C. S. SHERRINGTON, M.B., M.A., Fellow of Gonville and Caius College. Lecturer on Physiology in the School of St Thomas's Hospital, London. Plates II., III. and IV. From the Cambridge Pathological Laboratory. One marked characteristic of the literature dealing with the cerebral circulation is, we think, the contradictory nature of the results which have been obtained by different investigators. There is no reason, we imagine, for doubting that the cause of these discrepancies is to be found in the great difficulty of avoiding the sources of error which plentifully surround the subject, and in overcoming certain technical difficulties which we shall presently have to refer to. The ease with which one can obtain results upon certain points, on taking up the subject, is itself, we believe, apt to make the inquirer careless in controlling sources of error, which, it may be noted, are some of them not at first sight obvious. We must on this account say more about the technology of our subject than would be necessary were the subject a simpler one. Methods employed by other observers. In order that the bearing of our method may be understood, we think it well to refer to some of the other modes by which different observers have investigated the cerebral circulation. Some observers have simply inspected the exposed pia mater, as was done by Ha Her \ In most, if not all, of these experiments there appears to have been no simultaneous record taken of the arterial or venous pressure. That such a method, so rough in itself, could easily lead to untrustworthy results—giving as it does no means of distinguishing active changes in calibre of the cerebral vessels from passive variations of their width produced by changes in the arterial and venous pressures—will, we think, be readily admitted. 1 Ojicra Minora. Tom. i. p. 131.