A new synthesis of 4(or 5)-L-aminoethylglyoxaline, one of the active principles of ergot / by Frank Lee Pyman. The synthesis of r-histidine (preliminary note) / by Frank Lee Pyman.
- Pyman, Frank Lee.
- Date:
- [between 1910 and 1919?]
Licence: In copyright
Credit: A new synthesis of 4(or 5)-L-aminoethylglyoxaline, one of the active principles of ergot / by Frank Lee Pyman. The synthesis of r-histidine (preliminary note) / by Frank Lee Pyman. Source: Wellcome Collection.
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![92 (I), of which the sesquioxalate, (CnH1504N2Cl)4(C2H204)3, melts and decomposes at 176° (corr.). This base, on hydrolysis with 20 per cent, hydrochloric acid, gives r-a-chloro-fi-glyoxaline- 4(or 5)-propionic acid (II) [m. p. 201° (corr.)], which, when heated with strong ammonia at 110°, yields r-histidine (r-ct-amino- /3-glyoxaline--4(or 5)-propionic acid, (III) [melting and decomposing at 283° (corr.)], identical in all respects with that obtained by racemising the naturally-occurring amino-acid ^-histidine. —> CII2C1 + CNa01(C02Et)2 CH2*CCl(C02Et)2 (I.) i i CH2-CHC1-C02H 0ff2-CH(NH2)-C02 (II.) (III.) R. CLAY ANT) SONS, LTD., BREAD ST. HILL, E.C., AND BUNGAY, SUFFOLK.](https://iiif.wellcomecollection.org/image/b30622281_0002.jp2/full/800%2C/0/default.jpg)
