The composition of salvarsan / by Robert George Fargher and Frank Lee Pyman.
- Fargher, Robert George.
- Date:
- 1920.]
Licence: Public Domain Mark
Credit: The composition of salvarsan / by Robert George Fargher and Frank Lee Pyman. Source: Wellcome Collection.
8/8 page 377
![from concentrated methyl-alcoholic solution, and contained only 0-34 per cent, of sulphur. Other figures obtained on analysis indicated a normal composition. The second series of experiments, conducted by the converse process, namely, reduction of 3-nitro-4-hydroxyphenylarsinic acid to 3 : 37-dinitro-4 : 47-dihydroxyarsenobenzene and subsequent reduc¬ tion of the nitro-groups, was less successful. The first stage was readily accomplished by means of hypophos- phorous acid essentially as described in D.R.-P. 269886, although the somewhat elaborate precautions taken in isolating the product to ensure freedom from the corresponding diamine were found to be superfluous, since the reduction of the nitro-group by the addi¬ tion of potassium iodide to the reduction mixture (D.R.-P. 271894) could not be confirmed. Owing to its insolubility, dinitrodihydroxy arsenobenzene could not be reduced with sodium amalgam in acetic acid solution, and although in alkaline solution reduction took place readily, the product was unsatisfactory. The base obtained by reducing dinitrodihydroxyarsenobenzene in alkaline solution with sodium hyposulphite proved somewhat difficult to filter and wash. The hydrochloride prepared from it differed but little from commercial salvarsan. In conclusion, we are glad to have the opportunity of recording that this work was carried out in collaboration with the technical experts of Messrs. Burroughs Wellcome & Co., and to thank especially Dr. H. A. D. Jowett and Mr. F. H. Lees, F.I.C., for their valuable help and advice in the course of the work. The Wellcome Chemical Research Laboratories, London, E.C. 1. [Received, March 15th, 1920.] PRINTED IN GREAT BRITAIN BY R. CRAY AND SONS, LTD., BRUNSWICK STREET, STAMFORD STREET, S.E. I, AND BUNGAY, SUFFOLK.](https://iiif.wellcomecollection.org/image/b3062275x_0008.jp2/full/800%2C/0/default.jpg)
