Grave familial jaundice of the newly born / Sir Humphry Rolleston.

  • Humphry Rolleston
Date:
[1920?]
Catalogue details

Licence: In copyright

Credit: Grave familial jaundice of the newly born / Sir Humphry Rolleston. Source: Wellcome Collection.

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    of pregnancies; in Arkwright’s there were 15; in Auden’s, 12; in Underwood’s and Ritchie’s, 11, and in Busfield’s, Nason’s, and Morris’s, 10. Occasionally there are some miscarriages or premature births, but all the 11 pregnancies in the family reported by Ritchie went to full term. Some writers refer to the robust condition of the infants; but all Arkwright’s cases were rather weakly, and one had an intra-uterine amputation of the forearm. The disease appears to be less likely to attack the first and second born than the later infants in the families affected. The first-born escaped in the families reported by Arkwright, Smith, Auden, Bus- field, McGibbon, Morris, Tylecote, Still (two families), and the first two children in those reported by Abt (two families), Duguid, Nason, and Ashby and Wright. The first-born therefore escaped in 14 out of the 25 families collected, and in several families the first¬ born was slightly jaundiced and was the only one to recover. There is no evidence that syphilis plays any part in the disease, and though infection has been put forward as a cause, there is no good reason to accept this. The sex is not mentioned in some of the reports, but in those that I have collected there were 31 males and 31 females. The sex incidence thus differs from that of congenital hypertrophy of the pylorus and of congenital obliteration of the bile ducts, which are both, especially the former, much commoner in the male sex. It has occurred in twins (Still). Morbid Anatomy.—There is bile-staining of most of the tissues, and, as in physiological jaundice, there is selective staining of the lenticular and other nuclei in the brain, while the cortex escapes. Punctate haemorr¬ hages in the viscera are described, but their importance is doubtful, for they are not uncommon in stillborn children. There is no gross obstruction of the bile-
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