Grave familial jaundice of the newly born / Sir Humphry Rolleston.

  • Humphry Rolleston
Date:
[1920?]
Catalogue details

Licence: In copyright

Credit: Grave familial jaundice of the newly born / Sir Humphry Rolleston. Source: Wellcome Collection.

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    From “The Practitioner” for January, 1920. v * Grave Familial Jaundice of the Newly Born. By SIR HUMPHRY ROLLESTON, K.C.B., M.D., F.R.C.P. Emeritus Physician, St. George’s Hospital; Physician, Victoria Hospital for Children ; President of the Royal Society of Medicine, etc. RIEF Description.—In grave familial jaundice, successive infants become jaundiced a few hours to a day after birth, pass into a drowsy condition, and usually die within a week, often with convulsions; it resembles physiological jaundice in its onset, and, like it, does not show any gross post¬ mortem appearances to account for the jaundice. Pathogeny.—Pfannenstied regarded it as only an intensive form of the physiological jaundice, but not only is the prognosis very different, but there may be evidence of maternal toxaemia during the pregnancy. In three (Nason, Tylecote, Rolleston) out of the 25 family groups that I have collected—that is, in 15 out of 130 cases of newly-born infants with grave familial jaundice—the mothers had recurrent jaundice during their pregnancies. In the families reported by Smith and by Ritchie, the mothers had jaundice at the birth of one of the children, and in Arkwright’s family of 14 cases with four recoveries the mother had had jaundice when four years old and was always “ sallow.” In Blomfield’s cases, the mother suffered much from severe vomiting during the pregnancies, but this association appears to be exceptional. Against x P 4814—1
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